Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models
نویسندگان
چکیده
منابع مشابه
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Alzheimer's disease (AD) brains are characterized by amyloid-beta-containing plaques and hyperphosphorylated tau-containing neurofibrillary tangles (NFTs); however, in frontotemporal dementia, the tau pathology manifests in the absence of overt amyloid-beta plaques. Therapeutic strategies so far have primarily been targeting amyloid-beta, although those targeting tau are only slowly beginning t...
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The RNA-like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms underlying this association, we explored PERK activity in brains of PSP patients and its function in three tauopathy models (cultured human neurons overexpressing 4-repeat wild-type tau or treated with the environmental neurot...
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In Alzheimer's disease (AD), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with neuronal loss, is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of AD subjects suggests a sequence of initiation and subsequent spread of neurofibrillary tau tangles along defined brain anatomical pathways. Further, the severity o...
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Human toxicity Elemental selenium metal has a relatively low order of toxicity. Acute poisoning with selenium and its salts are rare, however, in excessive amount toxic and even fatal action was documented. Normal whole blood selenium levels in adults range from 0.085 to 0.13 mg/l [2]. All selenium salts can produce toxicity by ingestion, inhalation, and percutaneous absorption, although specif...
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Most dementing disorders result from a degenerating process named tauopathy. Alzheimer disease is the most frequent one, but only one among the large spectrum of tau-related diseases. Cognitive impairment is related, first of all, to the neocortical location of this degenerating process. However, the nature and the mechanisms leading to tauopathy can be very different. This is demonstrated by f...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1009038107